Answers: Where are you starting from?
Don't steal the bus. During rush hours street traffic will slow you down to a crawl. The subway would be faster and runs more frequntly.
But if you really want to do it by bus - if you are in Manhattan, the M1 and M6 bus runs down Broadway and stops any in front of the building or a block away.
Check the Manahttan Bus map:
http://mta.info/nyct/maps/manbus.pdf for a route essential you.
There is express bus service from Brooklyn but only one in Manhattan.
http://mta.info/nyct/bus/schedule/xpress...
I'd probably take a minicab.
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